Palladium-Catalyzed Acetylation of Arenes

[Image: see text] A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The met...

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Detalles Bibliográficos
Autores principales: Ramgren, Stephen D., Garg, Neil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937967/
https://www.ncbi.nlm.nih.gov/pubmed/24405108
http://dx.doi.org/10.1021/ol403570z
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author Ramgren, Stephen D.
Garg, Neil K.
author_facet Ramgren, Stephen D.
Garg, Neil K.
author_sort Ramgren, Stephen D.
collection PubMed
description [Image: see text] A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization.
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spelling pubmed-39379672015-01-09 Palladium-Catalyzed Acetylation of Arenes Ramgren, Stephen D. Garg, Neil K. Org Lett [Image: see text] A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization. American Chemical Society 2014-01-09 2014-02-07 /pmc/articles/PMC3937967/ /pubmed/24405108 http://dx.doi.org/10.1021/ol403570z Text en Copyright © 2014 American Chemical Society
spellingShingle Ramgren, Stephen D.
Garg, Neil K.
Palladium-Catalyzed Acetylation of Arenes
title Palladium-Catalyzed Acetylation of Arenes
title_full Palladium-Catalyzed Acetylation of Arenes
title_fullStr Palladium-Catalyzed Acetylation of Arenes
title_full_unstemmed Palladium-Catalyzed Acetylation of Arenes
title_short Palladium-Catalyzed Acetylation of Arenes
title_sort palladium-catalyzed acetylation of arenes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937967/
https://www.ncbi.nlm.nih.gov/pubmed/24405108
http://dx.doi.org/10.1021/ol403570z
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AT gargneilk palladiumcatalyzedacetylationofarenes

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