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Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells

Hyperinsulinemia is a major complication associated with the development of insulin resistance. In addition to its normal spectrum of metabolic effects, insulin can act as a growth factor and has the ability to promote mitogenic activity. Thus, hyperinsulinemia is regarded as a potentially important...

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Detalles Bibliográficos
Autores principales: Weinstein, Doron, Sarfstein, Rive, Laron, Zvi, Werner, Haim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938039/
https://www.ncbi.nlm.nih.gov/pubmed/24434591
http://dx.doi.org/10.1530/EC-13-0086