Cargando…

Hijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearance

The cellular prion protein PrP(c) is the normal counterpart of the scrapie prion protein PrP( Sc), the main component of the infectious agent of transmissible spongiform encephalopathies. The recent discovery that PrP( c) can serve as a receptor for the amyloid beta (Aβ) peptide and relay its neurot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernandez-Rapp, Julia, Martin-Lannerée, Séverine, Hirsch, Théo Z., Launay, Jean-Marie, Mouillet-Richard, Sophie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938157/ https://www.ncbi.nlm.nih.gov/pubmed/24592237 http://dx.doi.org/10.3389/fnagi.2014.00025

Ejemplares similares

PrP(C) from stem cells to cancer
por: Martin-Lannerée, Séverine, et al.
Publicado: (2014)

Pathogenic prions deviate PrP(C) signaling in neuronal cells and impair A-beta clearance
por: Pradines, E, et al.
Publicado: (2013)

A PrP(C)-caveolin-Lyn complex negatively controls neuronal GSK3β and serotonin 1B receptor
por: Hernandez-Rapp, Julia, et al.
Publicado: (2014)

A proof of concept for targeting the PrP(C) - Amyloid β peptide interaction in basal prostate cancer and mesenchymal colon cancer
por: Mouillet-Richard, Sophie, et al.
Publicado: (2022)

PrP(Sc) formation and clearance as determinants of prion tropism
por: Shikiya, Ronald A., et al.
Publicado: (2017)

To develop with or without the prion protein
por: Halliez, Sophie, et al.
Publicado: (2014)

The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018)

Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
por: Colini Baldeschi, Arianna, et al.
Publicado: (2022)

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

Mammalian prion propagation in PrP transgenic Drosophila
por: Thackray, Alana M, et al.
Publicado: (2018)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
por: Honda, Ryo P., et al.
Publicado: (2017)

Prion protein—Semisynthetic prion protein (PrP) variants with posttranslational modifications
por: Hackl, Stefanie, et al.
Publicado: (2019)

Prion protein localizes at the ciliary base during neural and cardiovascular development, and its depletion affects α-tubulin post-translational modifications
por: Halliez, Sophie, et al.
Publicado: (2015)

The Functional Role of Prion Protein (PrP(C)) on Autophagy
por: Shin, Hae-Young, et al.
Publicado: (2013)

The Multifaceted Functions of Prion Protein (PrP(C)) in Cancer
por: Abi Nahed, Roland, et al.
Publicado: (2023)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
por: Barron, Rona M., et al.
Publicado: (2016)

Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-Terminal Residues 23-88 Restores Susceptibility to 22L Prions, but Not to RML Prions in PrP-Knockout Mice
por: Uchiyama, Keiji, et al.
Publicado: (2014)

The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)
por: Yam, Alice Y., et al.
Publicado: (2010)

PrP(Sc)-Specific Antibodies with the Ability to Immunodetect Prion Oligomers
por: Tayebi, Mourad, et al.
Publicado: (2011)

Evidence That Bank Vole PrP Is a Universal Acceptor for Prions
por: Watts, Joel C., et al.
Publicado: (2014)

Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)
por: Srivastava, Saurabh, et al.
Publicado: (2018)

The prion 2018 round tables (I): the structure of PrP(Sc)
por: Baskakov, Ilia V., et al.
Publicado: (2019)

Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro
por: Workman, Rob G., et al.
Publicado: (2017)

Genetic human prion disease modelled in PrP transgenic Drosophila
por: Thackray, Alana M., et al.
Publicado: (2017)

Genetic modulation of CWD prion propagation in cervid PrP Drosophila
por: Thackray, Alana M., et al.
Publicado: (2023)

Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics
por: Jetha, Nahid N., et al.
Publicado: (2013)

PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2013)

Correction: PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2015)

Peroxiredoxin 6 promotes upregulation of the prion protein (PrP) in neuronal cells of prion-infected mice
por: Wagner, Wibke, et al.
Publicado: (2012)

Regional distribution of anchorless prion protein, PrP226*, in the human brain
por: Lukan, Anja, et al.
Publicado: (2014)

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways
por: Herrmann, Uli S., et al.
Publicado: (2015)

Heterogeneity of the Abnormal Prion Protein (PrP(Sc)) of the Chandler Scrapie Strain
por: Kasai, Kazuo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2572knqk4add2afodnihlj6229