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Abrogation of Rbpj Attenuates Experimental Autoimmune Uveoretinitis by Inhibiting IL-22-Producing CD4(+) T Cells
Experimental autoimmune uveoretinitis (EAU) is an organ-specific T cell-mediated disease induced by immunizing mice with interphotoreceptor retinoid binding protein (IRBP). Autoaggressive CD4(+) T cells are the major pathogenic population for EAU. We investigated the contribution of Notch signaling...
Autores principales: | Bhuyan, Zaied Ahmed, Asanoma, Michihito, Iwata, Akiko, Ishifune, Chieko, Maekawa, Yoichi, Shimada, Mitsuo, Yasutomo, Koji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938452/ https://www.ncbi.nlm.nih.gov/pubmed/24586644 http://dx.doi.org/10.1371/journal.pone.0089266 |
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