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Interferon-Gamma (IFN-γ)-Mediated Retinal Ganglion Cell Death in Human Tyrosinase T Cell Receptor Transgenic Mouse

We have recently demonstrated the characterization of human tyrosinase TCR bearing h3T-A2 transgenic mouse model, which exhibits spontaneous autoimmune vitiligo and retinal dysfunction. The purpose of current study was to determine the role of T cells and IFN-γ in retina dysfunction and retinal gang...

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Detalles Bibliográficos
Autores principales: Husain, Shahid, Abdul, Yasir, Webster, Christine, Chatterjee, Shilpak, Kesarwani, Pravin, Mehrotra, Shikhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938457/
https://www.ncbi.nlm.nih.gov/pubmed/24586745
http://dx.doi.org/10.1371/journal.pone.0089392