DNA Damage Induces Down-Regulation of Prp19 via Impairing Prp19 Stability in Hepatocellular Carcinoma Cells

Pre-mRNA processing factor 19 (Prp19) activates pre-mRNA spliceosome and also mediates DNA damage response. Prp19 overexpression in cells with functional p53 leads to decreased apoptosis and increases cell survival after DNA damage. Here we showed that in hepatocellular carcinoma (HCC) cells with in...

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Detalles Bibliográficos
Autores principales: Yin, Jie, Zhang, Yi-An, Liu, Tao-Tao, Zhu, Ji-Min, Shen, Xi-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938560/
https://www.ncbi.nlm.nih.gov/pubmed/24587161
http://dx.doi.org/10.1371/journal.pone.0089976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938560/
https://www.ncbi.nlm.nih.gov/pubmed/24587161
http://dx.doi.org/10.1371/journal.pone.0089976

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