Regulation of hERG and hEAG Channels by Src and by SHP-1 Tyrosine Phosphatase via an ITIM Region in the Cyclic Nucleotide Binding Domain

Members of the EAG K(+) channel superfamily (EAG/Kv10.x, ERG/Kv11.x, ELK/Kv12.x subfamilies) are expressed in many cells and tissues. In particular, two prototypes, EAG1/Kv10.1/KCNH1 and ERG1/Kv11.1/KCNH2 contribute to both normal and pathological functions. Proliferation of numerous cancer cells de...

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Detalles Bibliográficos
Autores principales: Schlichter, Lyanne C., Jiang, Jiahua, Wang, John, Newell, Evan W., Tsui, Florence W. L., Lam, Doris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938566/
https://www.ncbi.nlm.nih.gov/pubmed/24587194
http://dx.doi.org/10.1371/journal.pone.0090024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938566/
https://www.ncbi.nlm.nih.gov/pubmed/24587194
http://dx.doi.org/10.1371/journal.pone.0090024

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