Abrogation of TNFα Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12

For more than a decade, the cytokine interleukin-12 (IL-12) has been utilized, either alone or in combination with other drugs, as a treatment for cancer. The numerous anti-tumor properties of IL-12 still generate interest in the clinical use of this cytokine, even though it has demonstrated toxicit...

Descripción completa

Detalles Bibliográficos
Autores principales: Barrios, Bibiana, Baez, Natalia S., Reynolds, Della, Iribarren, Pablo, Cejas, Hugo, Young, Howard A., Rodriguez-Galan, Maria Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938584/
https://www.ncbi.nlm.nih.gov/pubmed/24587231
http://dx.doi.org/10.1371/journal.pone.0090116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938584/
https://www.ncbi.nlm.nih.gov/pubmed/24587231
http://dx.doi.org/10.1371/journal.pone.0090116

Ejemplares similares