NMR Characterization of the Near Native and Unfolded States of the PTB Domain of Dok1: Alternate Conformations and Residual Clusters

BACKGROUND: Phosphotyrosine binding (PTB) domains are critically involved in cellular signaling and diseases. PTB domains are categorized into three distinct structural classes namely IRS-like, Shc-like and Dab-like. All PTB domains consist of a core pleckstrin homology (PH) domain with additional s...

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Detalles Bibliográficos
Autores principales: Gupta, Sebanti, Bhattacharjya, Surajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938774/
https://www.ncbi.nlm.nih.gov/pubmed/24587391
http://dx.doi.org/10.1371/journal.pone.0090557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938774/
https://www.ncbi.nlm.nih.gov/pubmed/24587391
http://dx.doi.org/10.1371/journal.pone.0090557

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