Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Ataxia telangiectasia mutated (ATM) kinase plays an essential role in the maintenance of genomic stability. ATM-deficient (ATM(−/−)) mice exhibit hematopoietic stem cell (HSC) dysfunction and a high incidence of lymphoma. Gadd45a controls cell cycle arrest, apoptosis and DNA repair, and is involved...

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Detalles Bibliográficos
Autores principales: Chen, Yulin, Yang, Runan, Guo, Peng, Ju, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938854/
https://www.ncbi.nlm.nih.gov/pubmed/24474198
http://dx.doi.org/10.1007/s13238-013-0017-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938854/
https://www.ncbi.nlm.nih.gov/pubmed/24474198
http://dx.doi.org/10.1007/s13238-013-0017-9

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