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Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalisation

During apoptosis, phosphatidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and serves as an “eat-me” signal to trigger phagocytosis. It is poorly understood how PS exposure is activated in apoptotic cells. Here we report t...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Zen, Mapes, James, Lee, Eui-Seung, Skeen-Gaar, Riley Robert, Xue, Ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939056/
https://www.ncbi.nlm.nih.gov/pubmed/24225442
http://dx.doi.org/10.1038/ncomms3726