Activation of Akt Signaling in Prostate Induces a TGFβ Mediated Restraint on Cancer Progression and Metastasis

Mutations in the PTEN tumor suppressor gene are found in a high proportion of human prostate cancers, and in mice, Pten deletion induces high-grade prostate intra-epithelial neoplasia (HGPIN). However, progression from HGPIN to invasive cancer occurs slowly, suggesting that tumorigenesis is subject...

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Detalles Bibliográficos
Autores principales: Bjerke, Glen A., Yang, Chun-Song, Frierson, Henry F., Paschal, Bryce M., Wotton, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939071/
https://www.ncbi.nlm.nih.gov/pubmed/23995785
http://dx.doi.org/10.1038/onc.2013.342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939071/
https://www.ncbi.nlm.nih.gov/pubmed/23995785
http://dx.doi.org/10.1038/onc.2013.342

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