Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells

It has been recently ascribed to several inflammatory cytokines (i.e. TGF-β3, TNF-α, and IL-1) a functional role in regulating Sertoli cell blood-testis barrier (BTB) dynamics. In the testis, IL-6 inhibits meiotic DNA synthesis during the seminiferous epithelium cycle, reduces sperm motility and inf...

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Detalles Bibliográficos
Autores principales: Zhang, Huijuan, Yin, Yimeng, Wang, Guishuan, Liu, Zhimin, Liu, Lin, Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939460/
https://www.ncbi.nlm.nih.gov/pubmed/24584780
http://dx.doi.org/10.1038/srep04260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939460/
https://www.ncbi.nlm.nih.gov/pubmed/24584780
http://dx.doi.org/10.1038/srep04260

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