The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications

A long time has passed since the first clinical trial with adenoviral (Ad) vectors. Despite being very promising, Ad vectors soon revealed their limitations in human clinical trials. The pre-existing immunity, the marked liver tropism and the high toxicity of first generation Ad (FG-Ad) vectors have...

Descripción completa

Detalles Bibliográficos
Autores principales: Capasso, Cristian, Garofalo, Mariangela, Hirvinen, Mari, Cerullo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939484/
https://www.ncbi.nlm.nih.gov/pubmed/24549268
http://dx.doi.org/10.3390/v6020832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939484/
https://www.ncbi.nlm.nih.gov/pubmed/24549268
http://dx.doi.org/10.3390/v6020832

Ejemplares similares