Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity()

African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential. Nevertheless they can b...

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Detalles Bibliográficos
Autores principales: Lüscher, Alexandra, Lamprea-Burgunder, Estelle, Graf, Fabrice E., de Koning, Harry P., Mäser, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940079/
https://www.ncbi.nlm.nih.gov/pubmed/24596669
http://dx.doi.org/10.1016/j.ijpddr.2013.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940079/
https://www.ncbi.nlm.nih.gov/pubmed/24596669
http://dx.doi.org/10.1016/j.ijpddr.2013.12.001

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