Gpr48 Deficiency Induces Polycystic Kidney Lesions and Renal Fibrosis in Mice by Activating Wnt Signal Pathway

G protein-coupled receptor 48 (Gpr48/Lgr4) is essential to regulate the development of multiple tissues in mice. The notion that Gpr48 functions in renal development prompted us to investigate the relation between Gpr48 and renal diseases. Using a Gpr48 knockout mice model, we observed that 66.7% Gp...

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Detalles Bibliográficos
Autores principales: Dang, Yongyan, Liu, Bei, Xu, Peng, Zhu, Pingya, Zhai, Yimiao, Liu, Mingyao, Ye, Xiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940658/
https://www.ncbi.nlm.nih.gov/pubmed/24595031
http://dx.doi.org/10.1371/journal.pone.0089835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940658/
https://www.ncbi.nlm.nih.gov/pubmed/24595031
http://dx.doi.org/10.1371/journal.pone.0089835

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