The Curious Case of Benzbromarone: Insight into Super-Inhibition of Cytochrome P450

Cytochrome P450 (CYP) family of redox enzymes metabolize drugs and xenobiotics in liver microsomes. Isozyme CYP2C9 is reported to be inhibited by benzbromarone (BzBr) and this phenomenon was hitherto explained by classical active-site binding. Theoretically, it was impossible to envisage the experim...

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Detalles Bibliográficos
Autores principales: Parashar, Abhinav, Gade, Sudeep Kumar, Potnuru, Mahesh, Madhavan, Nandita, Manoj, Kelath Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940698/
https://www.ncbi.nlm.nih.gov/pubmed/24594849
http://dx.doi.org/10.1371/journal.pone.0089967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940698/
https://www.ncbi.nlm.nih.gov/pubmed/24594849
http://dx.doi.org/10.1371/journal.pone.0089967

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