Cargando…

The Curious Case of Benzbromarone: Insight into Super-Inhibition of Cytochrome P450

Cytochrome P450 (CYP) family of redox enzymes metabolize drugs and xenobiotics in liver microsomes. Isozyme CYP2C9 is reported to be inhibited by benzbromarone (BzBr) and this phenomenon was hitherto explained by classical active-site binding. Theoretically, it was impossible to envisage the experim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parashar, Abhinav, Gade, Sudeep Kumar, Potnuru, Mahesh, Madhavan, Nandita, Manoj, Kelath Murali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940698/ https://www.ncbi.nlm.nih.gov/pubmed/24594849 http://dx.doi.org/10.1371/journal.pone.0089967

Ejemplares similares

Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes
por: Manoj, Kelath Murali, et al.
Publicado: (2016)

Cytochrome P450 Reductase: A Harbinger of Diffusible Reduced Oxygen Species
por: Manoj, Kelath Murali, et al.
Publicado: (2010)

Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme ‘active site’ pocket plays a relatively ‘passive role’ in some enzyme-substrate interactions
por: Venkatachalam, Avanthika, et al.
Publicado: (2016)

Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses
por: Parashar, Abhinav, et al.
Publicado: (2018)

Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation
por: López, Laura C., et al.
Publicado: (2016)

The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone
por: Tadjuidje, Emmanuel, et al.
Publicado: (2012)

Aerobic Respiration: Criticism of the Proton-centric Explanation Involving Rotary Adenosine Triphosphate Synthesis, Chemiosmosis Principle, Proton Pumps and Electron Transport Chain
por: Manoj, Kelath Murali
Publicado: (2018)

Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone
por: Niu, Sheng-Wen, et al.
Publicado: (2022)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

Structural Insights on the Conversion of Cytochrome P450 to P420
por: Gable, Jessica A., et al.
Publicado: (2022)

Benzbromarone Stabilizes ΔF508 CFTR at the Cell Surface
por: Loo, Tip W., et al.
Publicado: (2011)

Cardiovascular risk associated with allopurinol vs. benzbromarone in patients with gout
por: Kang, Eun Ha, et al.
Publicado: (2021)

Cardiovascular risk associated with allopurinol or benzbromarone treatment in patients with gout
por: Eun, Yeonghee, et al.
Publicado: (2022)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes
por: Ryu, Chang Seon, et al.
Publicado: (2016)

Pharmacovigilance: Effects of herbal components on human drugs interactions involving Cytochrome P450
por: Saxena, Akansha, et al.
Publicado: (2008)

Liver failure associated with benzbromarone: A case report and review of the literature
por: Zhang, Ming-Yuan, et al.
Publicado: (2019)

Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans
por: Mujwar, Somdutt, et al.
Publicado: (2022)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies
por: Sridhar, Jayalakshmi, et al.
Publicado: (2012)

Water Complexes of Cytochrome P450: Insights from Energy Decomposition Analysis
por: Thellamurege, Nandun, et al.
Publicado: (2013)

Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis
por: Ebrecht, Ana C., et al.
Publicado: (2019)

Fungal cytochrome P450 database
por: Park, Jongsun, et al.
Publicado: (2008)

Cytochrome P450 humanised mice
por: Gonzalez, Frank J
Publicado: (2004)

Intronic polymorphisms of cytochromes P450
por: Ingelman-Sundberg, Magnus, et al.
Publicado: (2010)

The Role of Cytochromes P450 in Infection
por: Stavropoulou, Elisavet, et al.
Publicado: (2018)

Cytochromes P450, Oxygen, and Evolution
por: Lewis, David F.V., et al.
Publicado: (2001)

In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine
por: Chen, Yong, et al.
Publicado: (2010)

Comparative Cytochrome P450 In Vitro Inhibition by Atypical Antipsychotic Drugs
por: Gervasini, Guillermo, et al.
Publicado: (2013)

Inhibition of cytochrome P450 enzymes by thymoquinone in human liver microsomes
por: Albassam, Ahmed A., et al.
Publicado: (2018)

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A
por: Hassan, Reham, et al.
Publicado: (2022)

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
por: Zhang, Hai-Feng, et al.
Publicado: (2016)

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
por: de Montellano, Paul R Ortiz
Publicado: (2018)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Activating Effect of Benzbromarone, a Uricosuric Drug, on Peroxisome Proliferator-Activated Receptors
por: Kunishima, Chiyoko, et al.
Publicado: (2007)

Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer
por: Cotrina, Ellen Y., et al.
Publicado: (2020)

Sex differences in response to allopurinol and benzbromarone in gout: a retrospective cohort study
por: Veenstra, Frouwke, et al.
Publicado: (2021)

Comparison of Benzbromarone and Allopurinol on Primary Prevention of the First Gout Flare in Asymptomatic Hyperuricemia
por: Lai, Shih-Wei, et al.
Publicado: (2022)

Insights into the Role of Substrates on the Interaction between Cytochrome b(5) and Cytochrome P450 2B4 by NMR
por: Zhang, Meng, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rk7neub5iahjq4ago8pa89fji5