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Effect of C-Terminal Residues of Aβ on Copper Binding Affinity, Structural Conversion and Aggregation
Many properties of Aβ such as toxicity, aggregation and ROS formation are modulated by Cu(2+). Previously, the coordination configuration and interaction of Cu(2+) with the Aβ N-terminus has been extensively studied. However, the effect of Aβ C-terminal residues on related properties is still unclea...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940864/ https://www.ncbi.nlm.nih.gov/pubmed/24594588 http://dx.doi.org/10.1371/journal.pone.0090385 |