The Synthetic α-Bromo-2′,3,4,4′-Tetramethoxychalcone (α-Br-TMC) Inhibits the JAK/STAT Signaling Pathway

Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for mal...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinz, Sophia, Unser, Samy, Brueggemann, Susanne, Besl, Elisabeth, Al-Rifai, Nafisah, Petkes, Hermina, Amslinger, Sabine, Rascle, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940872/
https://www.ncbi.nlm.nih.gov/pubmed/24595334
http://dx.doi.org/10.1371/journal.pone.0090275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940872/
https://www.ncbi.nlm.nih.gov/pubmed/24595334
http://dx.doi.org/10.1371/journal.pone.0090275

Ejemplares similares