DNA-PKcs activates the Chk2–Brca1 pathway during mitosis to ensure chromosomal stability

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is known to have a critical role in DNA double-strand break repair. We have previously reported that DNA-PKcs is activated when cells enter mitosis and functions in mitotic spindle assembly and chromosome segregation. Here we report th...

Descripción completa

Detalles Bibliográficos
Autores principales: Shang, Z, Yu, L, Lin, Y-F, Matsunaga, S, Shen, C-Y, Chen, B P C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940919/
https://www.ncbi.nlm.nih.gov/pubmed/24492479
http://dx.doi.org/10.1038/oncsis.2013.49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940919/
https://www.ncbi.nlm.nih.gov/pubmed/24492479
http://dx.doi.org/10.1038/oncsis.2013.49

Ejemplares similares