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Macrophage Contact Dependent and Independent TLR4 Mechanisms Induce β-Cell Dysfunction and Apoptosis in a Mouse Model of Type 2 Diabetes

Type 2 diabetes (T2D) is evolving into a global disease and patients have a systemic low-grade inflammation, yet the role of this inflammation is still not established. One plausible mechanism is enhanced expression and activity of the innate immune system. Therefore, we evaluated the expression and...

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Detalles Bibliográficos
Autores principales:	Cucak, Helena, Mayer, Christopher, Tonnesen, Morten, Thomsen, Lise Høj, Grunnet, Lars Groth, Rosendahl, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940939/ https://www.ncbi.nlm.nih.gov/pubmed/24594974 http://dx.doi.org/10.1371/journal.pone.0090685

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