Effects of I(Kur) blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation

Selective blockers of the Kv1.5 channel have been developed for the treatment of atrial fibrillation (AF), but little is known how these atrial-selective drugs affect human action potentials (APs). Therefore we have investigated the Kv1.5 blocker MK-0448 (N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin...

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Detalles Bibliográficos
Autores principales: Loose, Simone, Mueller, Judith, Wettwer, Erich, Knaut, Michael, Ford, John, Milnes, James, Ravens, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940943/
https://www.ncbi.nlm.nih.gov/pubmed/24624083
http://dx.doi.org/10.3389/fphar.2014.00026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940943/
https://www.ncbi.nlm.nih.gov/pubmed/24624083
http://dx.doi.org/10.3389/fphar.2014.00026

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