Cargando…

Effects of I(Kur) blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation

Selective blockers of the Kv1.5 channel have been developed for the treatment of atrial fibrillation (AF), but little is known how these atrial-selective drugs affect human action potentials (APs). Therefore we have investigated the Kv1.5 blocker MK-0448 (N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loose, Simone, Mueller, Judith, Wettwer, Erich, Knaut, Michael, Ford, John, Milnes, James, Ravens, Ursula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940943/ https://www.ncbi.nlm.nih.gov/pubmed/24624083 http://dx.doi.org/10.3389/fphar.2014.00026

Ejemplares similares

The positive frequency-dependent electrophysiological effects of the I(Kur) inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation
por: Ford, John, et al.
Publicado: (2016)

Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation
por: Poulet, Claire, et al.
Publicado: (2015)

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation
por: Sánchez, Carlos, et al.
Publicado: (2014)

NO-donors induce cross talk between cGMP and cAMP in signalling to human atrial L-type Ca(2+) current
por: Rozmaritsa, Nadiia, et al.
Publicado: (2011)

Heterogeneity and Remodeling of Ion Currents in Cultured Right Atrial Fibroblasts From Patients With Sinus Rhythm or Atrial Fibrillation
por: Jakob, Dorothee, et al.
Publicado: (2021)

Teurer Kurs
Publicado: (1969)

Left atrial scar identification and quantification in sinus rhythm and atrial fibrillation
por: Mannion, James, et al.
Publicado: (2020)

Rotor Termination Is Critically Dependent on Kinetic Properties of I (Kur) Inhibitors in an In Silico Model of Chronic Atrial Fibrillation
por: Scholz, Eberhard P., et al.
Publicado: (2013)

Regierungsteilchen auf CERN-Crash-Kurs
Publicado: (2009)

P04.48. Fatty acids and dementia: systematic review and meta-analyses
por: Loef, M, et al.
Publicado: (2012)

Atrial contractile function and fibrosis in patients with paroxysmal atrial fibrillation in sinus rhythm
por: Yaroslav, Ashikhmin, et al.
Publicado: (2022)

Vom CERN-Physiker zur Elektronen-Kür
Publicado: (1980)

Analysis of immune cell populations in atrial myocardium of patients with atrial fibrillation or sinus rhythm
por: Smorodinova, Natalia, et al.
Publicado: (2017)

Atrial low voltage areas: A comparison between atrial fibrillation and sinus rhythm
por: Lahuerta, Ana Andrés, et al.
Publicado: (2022)

In Silico Assessment of Efficacy and Safety of I(Kur) Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding
por: Ellinwood, Nicholas, et al.
Publicado: (2017)

Redefining β-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis
por: Karwath, Andreas, et al.
Publicado: (2021)

Heat shock proteins in stabilization of spontaneously restored sinus rhythm in permanent atrial fibrillation patients after mitral valve surgery
por: Cao, Hailong, et al.
Publicado: (2011)

Atrial Fibrillation Recurrence Predictors after Conversion to Sinus Rhythm
por: MILITARU, C., et al.
Publicado: (2014)

Hyperkalemia Presenting as Sinus Bradycardia, Junctional Rhythm and Atrial Bigeminy
por: Hanumanthu, Balaram Krishna J, et al.
Publicado: (2019)

Inflammatory cell infiltration in left atrial appendageal tissues of patients with atrial fibrillation and sinus rhythm
por: Hohmann, Christopher, et al.
Publicado: (2020)

Atrial rhythm influences catheter tissue contact during radiofrequency catheter ablation of atrial fibrillation: comparison of contact force between sinus rhythm and atrial fibrillation
por: Matsuda, Hisao, et al.
Publicado: (2015)

Spontaneous Sinus Conversion of Permanent Atrial Fibrillation During Treatment of Hyperkalemia
por: Yoon, Ji Hyun, et al.
Publicado: (2012)

Complex fractionated atrial electrograms, high dominant frequency regions, and left atrial voltages during sinus rhythm and atrial fibrillation
por: Sasaki, Naoko, et al.
Publicado: (2017)

The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation
por: Murdock, David K, et al.
Publicado: (2008)

Effect of sinus rhythm restoration on markers of thrombin generation in atrial fibrillation
por: Horjen, Anja Wiedswang, et al.
Publicado: (2017)

The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm
por: van der Does, Lisette J. M. E., et al.
Publicado: (2019)

Conduction Disorders during Sinus Rhythm in Relation to Atrial Fibrillation Persistence
por: van der Does, Willemijn F. B., et al.
Publicado: (2021)

Properties of the transient outward, ultra-rapid delayed rectifier and acetylcholine-sensitive potassium currents in isolated atrial myocytes from dogs: sinus rhythm and tachypaced model of permanent atrial fibrillation
por: Kohajda, Zsófia, et al.
Publicado: (2011)

The efficacy and safety of amiodarone combined with beta-blockers in the maintenance of sinus rhythm for atrial fibrillation: A protocol for systematic review and network meta-analysis
por: Shi, Shuqing, et al.
Publicado: (2020)

Entrapment of focal atrial tachycardia using cryoballoon ablation; Sinus rhythm in the left atrium and ongoing atrial tachycardia in the left atrial appendage
por: Yorgun, Hikmet, et al.
Publicado: (2017)

Prediction of sinus rhythm maintenance following DC-cardioversion of persistent atrial fibrillation – the role of atrial cycle length
por: Meurling, Carl J, et al.
Publicado: (2006)

The Effects of Percutaneous Mitral Balloon Valvuloplasty on the Left Atrial Appendage Function in Patients With Sinus Rhythm and Atrial Fibrillation
por: Aslanabadi, Naser, et al.
Publicado: (2015)

Echocardiographic Evaluation of Atrial Remodelling for the Prognosis of Maintaining Sinus Rhythm after Electrical Cardioversion in Patients with Atrial Fibrillation
por: Wałek, Paweł, et al.
Publicado: (2023)

Critical Care Transthoracic Echocardiography: Atrial Sinus Rhythm During Ventricular Fibrillation
por: Schulman, Peter Mark, et al.
Publicado: (2014)

Spontaneous Normal Sinus Rhythm Conversion Using Integrative Medicine in Atrial Fibrillation
por: Farrar, Wendy S., et al.
Publicado: (2012)

Restoring Sinus Rhythm Improves Baroreflex Function in Patients With Persistent Atrial Fibrillation
por: Field, Michael E., et al.
Publicado: (2016)

Risk Factors for Recurrence of Atrial Fibrillation in Horses After Cardioversion to Sinus Rhythm
por: Decloedt, A., et al.
Publicado: (2015)

Clinical determinants of early spontaneous conversion to sinus rhythm in patients with atrial fibrillation
por: Pluymaekers, N. A. H. A., et al.
Publicado: (2021)

Clinical Relevance of Sinus Rhythm Mapping to Quantify Electropathology Related to Atrial Fibrillation
por: van Schie, Mathijs S, et al.
Publicado: (2022)

RELATIONSHIP OF LEFT VENTRICULAR SIZE TO LEFT ATRIAL AND LEFT ATRIAL APPENDAGE SIZE IN SINUS RHYTHM PATIENTS WITH DILATED CARDIOMYOPATHY
por: Bakalli, Aurora, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_fefgs64g8c60dl52nbpep1svsu