Molecular dynamics simulations highlight structural and functional alterations in deafness–related M34T mutation of connexin 26

Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widely expressed in the inner ear, are the primary cause of hereditary non-syndromic hearing loss in several populations. The deafness–associated single amino acid substitution of methionine 34 (M34) in the fir...

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Detalles Bibliográficos
Autores principales: Zonta, Francesco, Buratto, Damiano, Cassini, Chiara, Bortolozzi, Mario, Mammano, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941013/
https://www.ncbi.nlm.nih.gov/pubmed/24624091
http://dx.doi.org/10.3389/fphys.2014.00085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941013/
https://www.ncbi.nlm.nih.gov/pubmed/24624091
http://dx.doi.org/10.3389/fphys.2014.00085

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