Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed...

Descripción completa

Detalles Bibliográficos
Autores principales: Adachi, Kei, Enoki, Tatsuji, Kawano, Yasuhiro, Veraz, Michael, Nakai, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941020/
https://www.ncbi.nlm.nih.gov/pubmed/24435020
http://dx.doi.org/10.1038/ncomms4075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941020/
https://www.ncbi.nlm.nih.gov/pubmed/24435020
http://dx.doi.org/10.1038/ncomms4075

Ejemplares similares