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Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed...

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Detalles Bibliográficos
Autores principales:	Adachi, Kei, Enoki, Tatsuji, Kawano, Yasuhiro, Veraz, Michael, Nakai, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941020/ https://www.ncbi.nlm.nih.gov/pubmed/24435020 http://dx.doi.org/10.1038/ncomms4075

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