Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

The functional outcomes of ephrin binding to Eph receptors (Ephs) range from cell repulsion to adhesion. Here we used cell collapse and stripe assays to show contrasting effects of human ephrinA5 binding to EphA2 and EphA4. Despite equivalent ligand-binding affinities EphA4 triggered greater cell co...

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Detalles Bibliográficos
Autores principales: Seiradake, Elena, Schaupp, Andreas, Ruiz, Daniel del Toro, Kaufmann, Rainer, Mitakidis, Nikolaos, Harlos, Karl, Aricescu, A Radu, Klein, Rüdiger, Jones, E Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941021/
https://www.ncbi.nlm.nih.gov/pubmed/23812375
http://dx.doi.org/10.1038/nsmb.2617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941021/
https://www.ncbi.nlm.nih.gov/pubmed/23812375
http://dx.doi.org/10.1038/nsmb.2617

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