Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

Activation of the PI3K–Akt–FoxO pathway induces cell growth, whereas its inhibition reduces cell survival and, in muscle, causes atrophy. Here, we report a novel mechanism that suppresses PI3K–Akt–FoxO signaling. Although skeletal muscle lacks desmosomes, it contains multiple desmosomal components,...

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Detalles Bibliográficos
Autores principales: Cohen, Shenhav, Lee, Donghoon, Zhai, Bo, Gygi, Steven P., Goldberg, Alfred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941042/
https://www.ncbi.nlm.nih.gov/pubmed/24567360
http://dx.doi.org/10.1083/jcb.201304167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941042/
https://www.ncbi.nlm.nih.gov/pubmed/24567360
http://dx.doi.org/10.1083/jcb.201304167

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