Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. With beta cell self-replication being the primary source for new beta cell generation in adult animals, the network by which...

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Detalles Bibliográficos
Autores principales: Salas, Elisabet, Rabhi, Nabil, Froguel, Philippe, Annicotte, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941170/
https://www.ncbi.nlm.nih.gov/pubmed/24672805
http://dx.doi.org/10.1155/2014/873679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941170/
https://www.ncbi.nlm.nih.gov/pubmed/24672805
http://dx.doi.org/10.1155/2014/873679

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