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Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions
The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. With beta cell self-replication being the primary source for new beta cell generation in adult animals, the network by which...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941170/ https://www.ncbi.nlm.nih.gov/pubmed/24672805 http://dx.doi.org/10.1155/2014/873679 |