Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

BACKGROUND: There is extensive evidence for the role of aberrant cell survival signaling mechanisms in cancer progression and metastasis. Akt is a major component of cell survival-signaling mechanisms in several types of cancer. It has been shown that activated Akt stabilizes XIAP by S87 phosphoryla...

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Detalles Bibliográficos
Autores principales: Agarwal, Ekta, Chaudhuri, Anathbandhu, Leiphrakpam, Premila D, Haferbier, Katie L, Brattain, Michael G, Chowdhury, Sanjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941258/
https://www.ncbi.nlm.nih.gov/pubmed/24581231
http://dx.doi.org/10.1186/1471-2407-14-145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941258/
https://www.ncbi.nlm.nih.gov/pubmed/24581231
http://dx.doi.org/10.1186/1471-2407-14-145

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