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Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

BACKGROUND: There is extensive evidence for the role of aberrant cell survival signaling mechanisms in cancer progression and metastasis. Akt is a major component of cell survival-signaling mechanisms in several types of cancer. It has been shown that activated Akt stabilizes XIAP by S87 phosphoryla...

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Detalles Bibliográficos
Autores principales:	Agarwal, Ekta, Chaudhuri, Anathbandhu, Leiphrakpam, Premila D, Haferbier, Katie L, Brattain, Michael G, Chowdhury, Sanjib
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941258/ https://www.ncbi.nlm.nih.gov/pubmed/24581231 http://dx.doi.org/10.1186/1471-2407-14-145

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