E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1

OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex in vivo with E2 ubiquitin conjugating enzymes including UBC13 and UBCH5. OTUB1 binds to E2~Ub thioester intermediates and prevent ubiquitin transfer, thereby non-catalytically inhibiting accumulation of polyubiquitin. We report h...

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Detalles Bibliográficos
Autores principales: Wiener, Reuven, DiBello, Anthony T., Lombardi, Patrick, Guzzo, Catherine M., Zhang, Xiangbin, Matunis, Michael J., Wolberger, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941643/
https://www.ncbi.nlm.nih.gov/pubmed/23955022
http://dx.doi.org/10.1038/nsmb.2655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941643/
https://www.ncbi.nlm.nih.gov/pubmed/23955022
http://dx.doi.org/10.1038/nsmb.2655

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