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Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens: Implications for the Evolution of a Genetic Code Expansion Cassette

Pyrrolysine (Pyl), the 22nd proteogenic amino acid, was restricted until recently to few organisms. Its translational use necessitates the presence of enzymes for synthesizing it from lysine, a dedicated amber stop codon suppressor tRNA, and a specific amino-acyl tRNA synthetase. The three genomes o...

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Detalles Bibliográficos
Autores principales: Borrel, Guillaume, Gaci, Nadia, Peyret, Pierre, O'Toole, Paul W., Gribaldo, Simonetta, Brugère, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941956/
https://www.ncbi.nlm.nih.gov/pubmed/24669202
http://dx.doi.org/10.1155/2014/374146