Cargando…

Activating the Expression of Human K-ras(G12D) Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells

Humane use of preclinical large animal cancer models plays a critical role in understanding cancer biology and developing therapeutic treatments. Among the large animal candidates, goats have great potentials as sustainable sources for large animal cancer model development. Goats are easier to handl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Jianhua, Wang, Zhongde, Polejaeva, Irina, Salgia, Ravi, Kao, Chien-Min, Chen, Chin-Tu, Chen, Guangchun, Chen, Liaohai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942380/ https://www.ncbi.nlm.nih.gov/pubmed/24594684 http://dx.doi.org/10.1371/journal.pone.0090059

Ejemplares similares

Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells
por: Wang, Xiaojing, et al.
Publicado: (2014)

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System
por: Ni, Wei, et al.
Publicado: (2014)

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene
Publicado: (1995)

The Expression of Tumor Rejection Antigen on Rat Fetus Fibroblasts Transformed by the ras Oncogene
por: Okubo, Mamoru, et al.
Publicado: (1988)

Stable silencing of β-lactoglobulin (BLG) gene by lentivirus-mediated RNAi in goat fetal fibroblasts
por: Zhang, Shumin, et al.
Publicado: (2012)

The Role of Wild-Type RAS in Oncogenic RAS Transformation
por: Sheffels, Erin, et al.
Publicado: (2021)

Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system
por: Wu, Hua, et al.
Publicado: (2019)

Optimization of The Electroporation Conditions for Transfection of Human Factor IX into The Goat Fetal Fibroblasts
por: Amiri Yekta, Amir, et al.
Publicado: (2013)

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
por: Zhong, Chen, et al.
Publicado: (2019)

Ras Downstream Effector GGCT Alleviates Oncogenic Stress
por: He, Zaoke, et al.
Publicado: (2019)

Transforming ras oncogenes and multistage carcinogenesis.
por: Balmain, A.
Publicado: (1985)

Ras oncogene mutation in multiple myeloma
Publicado: (1989)

RAS: Striking at the Core of the Oncogenic Circuitry
por: Gimple, Ryan C., et al.
Publicado: (2019)

Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression.
por: Wyllie, A. H., et al.
Publicado: (1987)

Oncogenic H-Ras Expression Induces Fatty Acid Profile Changes in Human Fibroblasts and Extracellular Vesicles
por: Sagini, Krizia, et al.
Publicado: (2018)

Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains
por: Augsten, Martin, et al.
Publicado: (2014)

A high-fat diet increases the incidence of mammary cancer inc-Ha-ras proto-oncogene transgenic rats
por: Magaki, Mie, et al.
Publicado: (2016)

A quantitative transcriptomic analysis of the physiological significance of mTOR signaling in goat fetal fibroblasts
por: Fu, Yuting, et al.
Publicado: (2016)

Oncogenic Ras-Induced Proliferation Requires Autocrine Fibroblast Growth Factor 2 Signaling in Skeletal Muscle Cells
por: Fedorov, Yuri V., et al.
Publicado: (2001)

Fibroblast growth factor signaling and inhibition in non-small cell lung cancer and their role in squamous cell tumors
por: Salgia, Ravi
Publicado: (2014)

Oncogenic K-Ras and Basic Fibroblast Growth Factor Prevent FAS-Mediated Apoptosis in Fibroblasts through Activation of Mitogen-Activated Protein Kinase
por: Kazama, Hirotaka, et al.
Publicado: (2000)

The role of RAS oncogenes in controlling epithelial mechanics
por: Nyga, Agata, et al.
Publicado: (2023)

H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells
por: Li, C, et al.
Publicado: (2005)

Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung Adenocarcinomas
por: Sudhir, Putty-Reddy, et al.
Publicado: (2011)

Transgenic Rats Carrying Human c‐Ha‐ras Proto‐oncogene Are Highly Susceptible to N‐Nitrosomethylbenzylamine Induction of Esophageal Tumorigenesis
por: Asamoto, Makoto, et al.
Publicado: (2002)

PRG3 induces Ras-dependent oncogenic cooperation in gliomas
por: Fan, Zheng, et al.
Publicado: (2016)

Phosphoproteomics Analysis Reveals a Pivotal Mechanism Related to Amino Acid Signals in Goat Fetal Fibroblast
por: Zheng, Xu, et al.
Publicado: (2021)

Transgenic goats producing an improved version of cetuximab in milk
por: Laible, Götz, et al.
Publicado: (2020)

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
por: Zheng, Kang, et al.
Publicado: (2023)

Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras
por: Peng, Bo, et al.
Publicado: (2015)

c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts
Publicado: (1990)

Sos-mediated cross activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
por: Jeng, Hao-Hsuan, et al.
Publicado: (2012)

Mammary Carcinomas Induced in Human c‐Ha‐ras Proto‐oncogene Transgenic Rats Are Estrogen‐independent, but Responsive to d‐Limonene Treatment
por: Asamoto, Makoto, et al.
Publicado: (2002)

Ras oncogene mutations and survival in patients with lung cancer
por: Ferretti, G, et al.
Publicado: (2006)

Intercellular Transfer of Oncogenic H-Ras at the Immunological Synapse
por: Rechavi, Oded, et al.
Publicado: (2007)

Acute sensitivity of the oral mucosa to oncogenic K-ras
por: van der Weyden, Louise, et al.
Publicado: (2011)

Structure, signaling and the drug discovery of the Ras oncogene protein
por: Han, Chang Woo, et al.
Publicado: (2017)

Editorial: Oncogenic RAS-Dependent Reprogramming of Cellular Plasticity
por: Konstantinidou, Georgia, et al.
Publicado: (2020)

Small molecule inhibitors of RAS proteins with oncogenic mutations
por: Orgován, Zoltán, et al.
Publicado: (2020)

ZNF768 links oncogenic RAS to cellular senescence
por: Villot, Romain, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ddhmsdp7od9c8qme87oodt7j6e