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Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations
Any single-cell-resolved measurement generates a population distribution of phenotypes, characterized by a mean, a variance, and a shape. Here we show that changes in the shape of a phenotypic distribution can signal perturbations to cellular processes, providing a way to screen for underlying molec...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942435/ https://www.ncbi.nlm.nih.gov/pubmed/24594940 http://dx.doi.org/10.1371/journal.pone.0090540 |