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The basal transcription machinery as a target for cancer therapy

General transcription is required for the growth and survival of all living cells. However, tumor cells require extraordinary levels of transcription, including the transcription of ribosomal RNA genes by RNA polymerase I (RNPI) and mRNA by RNA polymerase II (RNPII). In fact, cancer cells have mutat...

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Detalles Bibliográficos
Autores principales: Villicaña, Claudia, Cruz, Grisel, Zurita, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942515/
https://www.ncbi.nlm.nih.gov/pubmed/24576043
http://dx.doi.org/10.1186/1475-2867-14-18