The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine—Feasibility of Orally Administrable Nucleoside Analogs

Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stability in buffers, enzymatic stability in cell homogenates, permeability in mouse intestinal membrane along with drug concentration in mouse plasma, and anti-proliferative activity in cancer cells were de...

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Detalles Bibliográficos
Autores principales: Tsume, Yasuhiro, Bermejo, Blanca Borras, Amidon, Gordon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942691/
https://www.ncbi.nlm.nih.gov/pubmed/24473270
http://dx.doi.org/10.3390/ph7020169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942691/
https://www.ncbi.nlm.nih.gov/pubmed/24473270
http://dx.doi.org/10.3390/ph7020169

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