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Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization
Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or enzymatic transformations, to the active parent mole...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942693/ https://www.ncbi.nlm.nih.gov/pubmed/24566521 http://dx.doi.org/10.3390/ph7020207 |