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β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation

The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundament...

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Detalles Bibliográficos
Autor principal: Lu, Christopher Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942788/
https://www.ncbi.nlm.nih.gov/pubmed/24583980
http://dx.doi.org/10.1038/ki.2013.419
Descripción
Sumario:The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular ROS on the one hand, with inflammation and cell death on the other hand.