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β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundament...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942788/ https://www.ncbi.nlm.nih.gov/pubmed/24583980 http://dx.doi.org/10.1038/ki.2013.419 |
Sumario: | The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular ROS on the one hand, with inflammation and cell death on the other hand. |
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