β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation

The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundament...

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Autor principal: Lu, Christopher Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942788/
https://www.ncbi.nlm.nih.gov/pubmed/24583980
http://dx.doi.org/10.1038/ki.2013.419
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author Lu, Christopher Y.
author_facet Lu, Christopher Y.
author_sort Lu, Christopher Y.
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description The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular ROS on the one hand, with inflammation and cell death on the other hand.
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spelling pubmed-39427882014-09-01 β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation Lu, Christopher Y. Kidney Int Article The clinical utility of cisplatin is limited by nephrotoxicity. So et al report that β-lapachone prevents this nephrotoxicity but not cisplatin’s cytotoxicity for cancers. In addition to its potential clinical importance, the beneficial effect of β-lapachone on cisplatin AKI may illustrate fundamental processes that ordinarily link alterations in nutrient availability and intracellular ROS on the one hand, with inflammation and cell death on the other hand. 2014-03 /pmc/articles/PMC3942788/ /pubmed/24583980 http://dx.doi.org/10.1038/ki.2013.419 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lu, Christopher Y.
β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
title β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
title_full β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
title_fullStr β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
title_full_unstemmed β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
title_short β-lapachone ameliorates murine cisplatin nephrotoxicty – NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
title_sort β-lapachone ameliorates murine cisplatin nephrotoxicty – nad+, nqo1, and sirt1 at the crossroads of metabolism, injury, and inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942788/
https://www.ncbi.nlm.nih.gov/pubmed/24583980
http://dx.doi.org/10.1038/ki.2013.419
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