Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species

There are two arylhydrocarbon receptor (AhR) isoforms in birds, AhR1 and AhR2. The varying sensitivity of AhR is reported to be related to two critical amino acids at positions 325 and 381 in the AhR1 ligand-binding domain. In this study, seven avian species whose in vivo dioxin sensitivity was know...

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Autores principales: FUJISAWA, Nozomi, KAWAI, Yusuke K., NAKAYAMA, Shouta M. M., IKENAKA, Yoshinori, YAMAMOTO, Hideaki, ISHIZUKA, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2013
Materias:
Wildlife Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942959/
https://www.ncbi.nlm.nih.gov/pubmed/23912877
http://dx.doi.org/10.1292/jvms.13-0179
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author FUJISAWA, Nozomi
KAWAI, Yusuke K.
NAKAYAMA, Shouta M. M.
IKENAKA, Yoshinori
YAMAMOTO, Hideaki
ISHIZUKA, Mayumi
author_facet FUJISAWA, Nozomi
KAWAI, Yusuke K.
NAKAYAMA, Shouta M. M.
IKENAKA, Yoshinori
YAMAMOTO, Hideaki
ISHIZUKA, Mayumi
author_sort FUJISAWA, Nozomi
collection PubMed
description There are two arylhydrocarbon receptor (AhR) isoforms in birds, AhR1 and AhR2. The varying sensitivity of AhR is reported to be related to two critical amino acids at positions 325 and 381 in the AhR1 ligand-binding domain. In this study, seven avian species whose in vivo dioxin sensitivity was known, and 13 species with no data regarding their in vivo dioxin sensitivity were examined. The two critical amino acids in the ligand-binding domain were investigated in avian species, and the results were compared with the taxonomy or phylogenetic trees for the bird AhR proteins. We found that the two critical amino acids did not correlate with the taxonomy or phylogeny of these proteins, suggesting that dioxin sensitivity was independent of taxonomy.
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spelling pubmed-39429592014-04-22 Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species FUJISAWA, Nozomi KAWAI, Yusuke K. NAKAYAMA, Shouta M. M. IKENAKA, Yoshinori YAMAMOTO, Hideaki ISHIZUKA, Mayumi J Vet Med Sci Wildlife Science There are two arylhydrocarbon receptor (AhR) isoforms in birds, AhR1 and AhR2. The varying sensitivity of AhR is reported to be related to two critical amino acids at positions 325 and 381 in the AhR1 ligand-binding domain. In this study, seven avian species whose in vivo dioxin sensitivity was known, and 13 species with no data regarding their in vivo dioxin sensitivity were examined. The two critical amino acids in the ligand-binding domain were investigated in avian species, and the results were compared with the taxonomy or phylogenetic trees for the bird AhR proteins. We found that the two critical amino acids did not correlate with the taxonomy or phylogeny of these proteins, suggesting that dioxin sensitivity was independent of taxonomy. The Japanese Society of Veterinary Science 2013-08-02 2013-12 /pmc/articles/PMC3942959/ /pubmed/23912877 http://dx.doi.org/10.1292/jvms.13-0179 Text en ©2013 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Wildlife Science
FUJISAWA, Nozomi
KAWAI, Yusuke K.
NAKAYAMA, Shouta M. M.
IKENAKA, Yoshinori
YAMAMOTO, Hideaki
ISHIZUKA, Mayumi
Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
title Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
title_full Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
title_fullStr Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
title_full_unstemmed Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
title_short Dioxin Sensitivity-Related Two Critical Amino Acids of Arylhydrocarbon Receptor May Not Correlate with the Taxonomy or Phylogeny in Avian Species
title_sort dioxin sensitivity-related two critical amino acids of arylhydrocarbon receptor may not correlate with the taxonomy or phylogeny in avian species
topic Wildlife Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942959/
https://www.ncbi.nlm.nih.gov/pubmed/23912877
http://dx.doi.org/10.1292/jvms.13-0179
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