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Total synthesis and cytotoxicity of the marine natural product malevamide D and a photoreactive analog

The marine natural product malevamide D from the cyanobacterium Symploca hydnoides was synthesized for the first time. The final peptide coupling linked the dolaisoleuine and dolaproine subunits. The phenyl group of malevamide D was also functionalized with a photoreactive diazirine moiety, which wa...

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Detalles Bibliográficos
Autores principales: Telle, Werner, Kelter, Gerhard, Fiebig, Heinz-Herbert, Jones, Peter G, Lindel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943603/
https://www.ncbi.nlm.nih.gov/pubmed/24605152
http://dx.doi.org/10.3762/bjoc.10.29