NK1 (TACR1) Receptor Gene ‘Knockout’ Mouse Phenotype Predicts Genetic Association with ADHD

Mice with functional genetic ablation of the Tacr1 (substance P-preferring receptor) gene (NK1R−/−) are hyperactive. Here, we investigated whether this is mimicked by NK1R antagonism and whether dopaminergic transmission is disrupted in brain regions that govern motor performance. The locomotor acti...

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Detalles Bibliográficos
Autores principales: Yan, TC, McQuillin, A, Thapar, A, Asherson, P, Hunt, SP, Stanford, SC, Gurling, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943619/
https://www.ncbi.nlm.nih.gov/pubmed/19204064
http://dx.doi.org/10.1177/0269881108100255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943619/
https://www.ncbi.nlm.nih.gov/pubmed/19204064
http://dx.doi.org/10.1177/0269881108100255

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