p62/SQSTM1 Accumulation in Squamous Cell Carcinoma of Head and Neck Predicts Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitors

The phosphoinositol-3 kinase (PI3K) pathway is highly dysregulated in squamous cell carcinoma of the head and neck (SCCHN). While inhibitors of the PI3K/AKT pathway are being developed in cancer, their efficacy does not appear to be related to the presence of mutations or amplification in pathway ge...

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Detalles Bibliográficos
Autores principales: Kuo, Wen-Liang, Sharifi, Marina N., Lingen, Mark W., Ahmed, Omar, Liu, Jing, Nagilla, Madhavi, Macleod, Kay F., Cohen, Ezra E. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943907/
https://www.ncbi.nlm.nih.gov/pubmed/24599075
http://dx.doi.org/10.1371/journal.pone.0090171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943907/
https://www.ncbi.nlm.nih.gov/pubmed/24599075
http://dx.doi.org/10.1371/journal.pone.0090171

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