Polycomb Binding Precedes Early-Life Stress Responsive DNA Methylation at the Avp Enhancer

Early-life stress (ELS) in mice causes sustained hypomethylation at the downstream Avp enhancer, subsequent overexpression of hypothalamic Avp and increased stress responsivity. The sequence of events leading to Avp enhancer methylation is presently unknown. Here, we used an embryonic stem cell-deri...

Descripción completa

Detalles Bibliográficos
Autores principales: Murgatroyd, Chris, Spengler, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943912/
https://www.ncbi.nlm.nih.gov/pubmed/24599304
http://dx.doi.org/10.1371/journal.pone.0090277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943912/
https://www.ncbi.nlm.nih.gov/pubmed/24599304
http://dx.doi.org/10.1371/journal.pone.0090277

Ejemplares similares