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Polycomb Binding Precedes Early-Life Stress Responsive DNA Methylation at the Avp Enhancer
Early-life stress (ELS) in mice causes sustained hypomethylation at the downstream Avp enhancer, subsequent overexpression of hypothalamic Avp and increased stress responsivity. The sequence of events leading to Avp enhancer methylation is presently unknown. Here, we used an embryonic stem cell-deri...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943912/ https://www.ncbi.nlm.nih.gov/pubmed/24599304 http://dx.doi.org/10.1371/journal.pone.0090277 |