A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

Entolimod (CBLB502) is a Toll-like receptor 5 agonist in development as a single-dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the “Animal Rule” does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000...

Descripción completa

Detalles Bibliográficos
Autores principales: Howell, B A, Siler, S Q, Shoda, L K M, Yang, Y, Woodhead, J L, Watkins, P B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944113/
https://www.ncbi.nlm.nih.gov/pubmed/24500662
http://dx.doi.org/10.1038/psp.2013.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944113/
https://www.ncbi.nlm.nih.gov/pubmed/24500662
http://dx.doi.org/10.1038/psp.2013.74

Ejemplares similares