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A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

Entolimod (CBLB502) is a Toll-like receptor 5 agonist in development as a single-dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the “Animal Rule” does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000...

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Detalles Bibliográficos
Autores principales:	Howell, B A, Siler, S Q, Shoda, L K M, Yang, Y, Woodhead, J L, Watkins, P B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944113/ https://www.ncbi.nlm.nih.gov/pubmed/24500662 http://dx.doi.org/10.1038/psp.2013.74

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